Shared genetics in coeliac disease and other immune-mediated diseases
نویسندگان
چکیده
منابع مشابه
Genetics in coeliac disease.
Coeliac disease has a strong genetic component, higher than for many other common complex diseases. Possession of the HLA-DQ2 variant is required for presentation of disease causing dietary antigens to T cells, although this is also common in the healthy population. Non-HLA genetic factors account for the majority of heritable risk. Linkage studies have identified promising regions on chromosom...
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Immune competence is provided and maintained by two cellular systems which involve lymphocytes, produced by the body's primary (bone marrow and thymus) and secondary (lymph nodes and spleen) lymphatic organs. They are descendants of the bone marrow's pool of stem cells, and constitute a circulating or humoral immune system derived from B-cells (bursa-dependent or bone marrow derived), and a cel...
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Fourteen coeliac patients on a gluten free diet (GFD) and 10 on a normal diet were studied by lymphocyte transformation in response to PHA to assess the integrity of cell-mediated immunity (CMI). Transformation was depressed in the majority taking a normal diet, with improvement after a GFD. In some patients the depression may have been due to a serum factor, as transformation was more nearly n...
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ژورنال
عنوان ژورنال: Journal of Internal Medicine
سال: 2011
ISSN: 0954-6820
DOI: 10.1111/j.1365-2796.2011.02375.x